Safety of hypertonic solution
"isotonic" solution defined as 250-375mOsm
Hypertonic saline dextran (HSD)
- 7.5% NaCl + 6% dextran
- = 2567mOsm/L
- Has been used in human resuscitation in dose of 4ml/kg or 250ml
3% HS: administration via peripheral IV endorsed by AHFS & uptodate
TPN
- Often believed that osm >600-900mOsm may cause phlebitis
Solution |
Osm |
D5 |
260 |
D10 |
500-555 |
D20 |
1010 |
D50 |
2500 |
20% mannitol |
1098 |
8.4% NaHCO3 |
2000 |
3% HS |
1027 |
5.85% HS |
2000 |
23.8% HS |
8200 |
KCl 20mmol in 100ml H2O |
400 |
KCl 20mmol in 100ml NS |
677 |
Osmolarity Calculator - Extremely powerful tool for compounding solutions (globalrph.com)