Safety of hypertonic solution
"isotonic" solution defined as 250-375mOsm
Hypertonic saline dextran (HSD)
- 7.5% NaCl + 6% dextran
- = 2567mOsm/L
- Has been used in human resuscitation in dose of 4ml/kg or 250ml
3% HS: administration via peripheral IV endorsed by AHFS & uptodate
TPN
- Often believed that osm >600-900mOsm may cause phlebitis
Solution | Osm |
D5 | 260 |
D10 | 500-555 |
D20 | 1010 |
D50 | 2500 |
20% mannitol | 1098 |
8.4% NaHCO3 | 2000 |
3% HS | 1027 |
5.85% HS | 2000 |
23.8% HS | 8200 |
KCl 20mmol in 100ml H2O | 400 |
KCl 20mmol in 100ml NS | 677 |
Osmolarity Calculator - Extremely powerful tool for compounding solutions (globalrph.com)